Ontology highlight
ABSTRACT:
SUBMITTER: Amouroux R
PROVIDER: S-EPMC2875005 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Amouroux Rachel R Campalans Anna A Epe Bernd B Radicella J Pablo JP
Nucleic acids research 20100113 9
How DNA repair machineries detect and access, within the context of chromatin, lesions inducing little or no distortion of the DNA structure is a poorly understood process. Removal of oxidized bases is initiated by a DNA glycosylase that recognises and excises the damaged base, initiating the base excision repair (BER) pathway. We show that upon induction of 8-oxoguanine, a mutagenic product of guanine oxidation, the mammalian 8-oxoguanine DNA glycosylase OGG1 is recruited together with other pr ...[more]