Ontology highlight
ABSTRACT:
SUBMITTER: Roccaro AM
PROVIDER: S-EPMC2875093 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Roccaro Aldo M AM Sacco Antonio A Aujay Monette M Ngo Hai T HT Azab Abdel Kareem AK Azab Feda F Quang Phong P Maiso Patricia P Runnels Judith J Anderson Kenneth C KC Demo Susan S Ghobrial Irene M IM
Blood 20100128 20
Proteasome inhibition represents a valid antitumor approach and its use has been validated in Waldenström macroglobulinemia (WM), where bortezomib has been successfully tested in clinical trials. Nevertheless, a significant fraction of patients relapses, and many present toxicity due to its off-target effects. Selective inhibition of the chymotrypsin-like (CT-L) activity of constitutive proteasome 20S (c20S) and immunoproteasome 20S (i20S) represents a sufficient and successful strategy to induc ...[more]