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Modeling spectral tuning in monomeric teal fluorescent protein mTFP1.


ABSTRACT: We present results of theoretical studies of the variants of the monomeric teal fluorescent protein from Clavularia coral (mTFP1) which present promising members from the GFP family. Predictions of quantum chemical approaches including density functional theory and semiempirical approximations are presented for the model systems which mimic the chromophores in different environments. We describe the excitation energy spectrum of the cyan mTFP1 fluorescent protein with the original chromophore and with chromophore mutants Tyr67His and Tyr67Trp.

SUBMITTER: Topol I 

PROVIDER: S-EPMC2875285 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Modeling spectral tuning in monomeric teal fluorescent protein mTFP1.

Topol Igor I   Collins Jack J   Nemukhin Alexander A  

Biophysical chemistry 20100410 3


We present results of theoretical studies of the variants of the monomeric teal fluorescent protein from Clavularia coral (mTFP1) which present promising members from the GFP family. Predictions of quantum chemical approaches including density functional theory and semiempirical approximations are presented for the model systems which mimic the chromophores in different environments. We describe the excitation energy spectrum of the cyan mTFP1 fluorescent protein with the original chromophore an  ...[more]

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