Ontology highlight
ABSTRACT:
SUBMITTER: Kabbarah O
PROVIDER: S-EPMC2875381 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Kabbarah Omar O Nogueira Cristina C Feng Bin B Nazarian Rosalynn M RM Bosenberg Marcus M Wu Min M Scott Kenneth L KL Kwong Lawrence N LN Xiao Yonghong Y Cordon-Cardo Carlos C Granter Scott R SR Ramaswamy Sridhar S Golub Todd T Duncan Lyn M LM Wagner Stephan N SN Brennan Cameron C Chin Lynda L
PloS one 20100524 5
A cardinal feature of malignant melanoma is its metastatic propensity. An incomplete view of the genetic events driving metastatic progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for melanoma patients. In this study, we conducted global genomic characterization of primary and metastatic melanomas to examine the genomic landscape associated with metastatic progression. In addition to uncovering three genomic subclasses of metastast ...[more]