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A 24-week, randomized, treat-to-target trial comparing initiation of insulin glargine once-daily with insulin detemir twice-daily in patients with type 2 diabetes inadequately controlled on oral glucose-lowering drugs.


ABSTRACT: OBJECTIVE:To determine whether glargine is noninferior to detemir regarding the percentage of patients reaching A1C <7% without symptomatic hypoglycemia

SUBMITTER: Swinnen SG 

PROVIDER: S-EPMC2875419 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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A 24-week, randomized, treat-to-target trial comparing initiation of insulin glargine once-daily with insulin detemir twice-daily in patients with type 2 diabetes inadequately controlled on oral glucose-lowering drugs.

Swinnen Sanne G SG   Dain Marie-Paule MP   Aronson Ronnie R   Davies Melanie M   Gerstein Hertzel C HC   Pfeiffer Andreas F AF   Snoek Frank J FJ   Devries J Hans JH   Hoekstra Joost B JB   Holleman Frits F  

Diabetes care 20100303 6


<h4>Objective</h4>To determine whether glargine is noninferior to detemir regarding the percentage of patients reaching A1C <7% without symptomatic hypoglycemia <or=3.1 mmol/l.<h4>Research design and methods</h4>In this 24-week trial, 973 insulin-naive type 2 diabetic patients on stable oral glucose-lowering drugs with A1C 7.0-10.5% were randomized to glargine once daily or detemir twice daily. Insulin doses were systematically titrated. RESULTS 27.5 and 25.6% of patients reached the primary out  ...[more]

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