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Argon neuroprotection.

ABSTRACT: Certain noble gases, though inert, exhibit remarkable biological properties. Notably, xenon and argon provide neuroprotection in animal models of central nervous system injury. In the previous issue of Critical Care, Loetscher and colleagues provided further evidence that argon may have therapeutic properties for neuronal toxicity by demonstrating protection against both traumatic and oxygen-glucose deprivation injury of organotypic hippocampal cultures in vitro. Their data are of interest as argon is more abundant, and therefore cheaper, than xenon (the latter of which is currently in clinical trials for perinatal hypoxic-ischemic brain injury; TOBYXe; NCT00934700). We eagerly await in vivo data to complement the promising in vitro data hailing argon neuroprotection.

SUBMITTER: Sanders RD

PROVIDER: S-EPMC2875517 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

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Argon neuroprotection.

Sanders Robert D RD Ma Daqing D Maze Mervyn M

Critical care (London, England) 20100222 1

Certain noble gases, though inert, exhibit remarkable biological properties. Notably, xenon and argon provide neuroprotection in animal models of central nervous system injury. In the previous issue of Critical Care, Loetscher and colleagues provided further evidence that argon may have therapeutic properties for neuronal toxicity by demonstrating protection against both traumatic and oxygen-glucose deprivation injury of organotypic hippocampal cultures in vitro. Their data are of interest as ar ...[more]

PMID: 20236500

Similar Datasets

Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets.

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| S-EPMC4252035 | biostudies-literature

Argon Inhalation for 24 Hours After Onset of Permanent Focal Cerebral Ischemia in Rats Provides Neuroprotection and Improves Neurologic Outcome.

Project description:OBJECTIVES:We tested the hypothesis that prolonged inhalation of 70% argon for 24 hours after in vivo permanent or temporary stroke provides neuroprotection and improves neurologic outcome and overall recovery after 7 days. DESIGN:Controlled, randomized, double-blinded laboratory study. SETTING:Animal research laboratories. SUBJECTS:Adult Wistar male rats (n = 110). INTERVENTIONS:Rats were subjected to permanent or temporary focal cerebral ischemia via middle cerebral artery occlusion, followed by inhalation of 70% argon or nitrogen in 30% oxygen for 24 hours. On postoperative day 7, a 48-point neuroscore and histologic lesion size were assessed. MEASUREMENTS AND MAIN RESULTS:After argon inhalation for 24 hours immediately following "severe permanent ischemia" induction, neurologic outcome (neuroscore, p = 0.034), overall recovery (body weight, p = 0.02), and infarct volume (total infarct volume, p = 0.0001; cortical infarct volume, p = 0.0003; subcortical infarct volume, p = 0.0001) were significantly improved. When 24-hour argon treatment was delayed for 2 hours after permanent stroke induction or until after postischemic reperfusion treatment, neurologic outcomes remained significantly improved (neuroscore, p = 0.043 and p = 0.014, respectively), as was overall recovery (body weight, p = 0.015), compared with nitrogen treatment. However, infarct volume and 7-day mortality were not significantly reduced when argon treatment was delayed. CONCLUSIONS:Neurologic outcome (neuroscore), overall recovery (body weight), and infarct volumes were significantly improved after 24-hour inhalation of 70% argon administered immediately after severe permanent stroke induction. Neurologic outcome and overall recovery were also significantly improved even when argon treatment was delayed for 2 hours or until after reperfusion.

| S-EPMC6629476 | biostudies-literature

Stable Lithium Argon compounds under high pressure.

Project description:High pressure can fundamentally alter the bonding patterns of chemical elements. Its effects include stimulating elements thought to be "inactive" to form unexpectedly stable compounds with unusual chemical and physical properties. Here, using an unbiased structure search method based on CALYPSO methodology and density functional total energy calculations, the phase stabilities and crystal structures of Li-Ar compounds are systematically investigated at high pressure up to 300?GPa. Two unexpected LimArn compounds (LiAr and Li3Ar) are predicted to be stable above 112?GPa and 119?GPa, respectively. A detailed analysis of the electronic structure of LiAr and Li3Ar shows that Ar in these compounds attracts electrons and thus behaves as an oxidizing agent. This is markedly different from the hitherto established chemical reactivity of Ar. Moreover, we predict that the P4/mmm phase of Li3Ar has a superconducting transition temperature of 17.6?K at 120?GPa.

| S-EPMC4652216 | biostudies-literature

Hybrid argon plasma coagulation for Barrett's esophagus.

Project description:Video 1Hybrid APC for Barrett's esophagus.

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Fate of subducted argon in the deep mantle.

Project description:The physical properties of argon (Ar) are investigated to 382?GPa and 3000?K using diamond anvil cell experiments and first-principles molecular dynamics. The estimated density of Ar is smaller that of the Preliminary reference Earth model (PREM) mantle, which indicates that the density crossover does not occur at the bottom of the lower mantle. A large volume dependence of the thermal pressure of Ar is revealed at pressures higher than 200?GPa, and a significant temperature dependence of the calculated effective Grüneisen parameters is confirmed at high pressures. A melting temperature of Ar is estimated from the calculation data and a significant pressure dependence is confirmed. If the pressure-temperature path of the subducted slab is lower than the critical condition, ~750?K and ~7.5?GPa, solid Ar can be carried down into the deep mantle. Melting of solid Ar in the upwelling mantle plume occurs at the bottom of the transition zone. Thus, solid Ar plays an important role in Ar recycling in the Earth's interior.

| S-EPMC6997185 | biostudies-literature

Rational design of an argon-binding superelectrophilic anion.

Project description:Chemically binding to argon (Ar) at room temperature has remained the privilege of the most reactive electrophiles, all of which are cationic (or even dicationic) in nature. Herein, we report a concept for the rational design of anionic superelectrophiles that are composed of a strong electrophilic center firmly embedded in a negatively charged framework of exceptional stability. To validate our concept, we synthesized the percyano-dodecoborate [B12(CN)12]2-, the electronically most stable dianion ever investigated experimentally. It serves as a precursor for the generation of the monoanion [B12(CN)11]-, which indeed spontaneously binds Ar at 298 K. Our mass spectrometric and spectroscopic studies are accompanied by high-level computational investigations including a bonding analysis of the exceptional B-Ar bond. The detection and characterization of this highly reactive, structurally stable anionic superelectrophile starts another chapter in the metal-free activation of particularly inert compounds and elements.

| S-EPMC6486711 | biostudies-literature

The role of argon in stroke.

Project description:Stroke, also known as "cerebrovascular accident", is an acute cerebrovascular disease that is caused by a sudden rupture of blood vessels in the brain or obstruction of the blood supply by blockage of blood vessels, thus including hemorrhagic and ischemic strokes. The incidence of ischemic stroke is higher than that of hemorrhagic stroke, and accounts for 80% of the total number of strokes. However, the mortality rate of hemorrhagic stroke is relatively high. Internal carotid artery and vertebral artery occlusion and stenosis can cause ischemic stroke, and especially males over 40 years of age are at a high risk of morbidity. According to the survey, stroke in urban and rural areas has become the first cause of death in China. It is also the leading cause of disability in Chinese adults. In a word, stroke is characterized by high morbidity, high mortality and high disability rates. Studies have shown that many noble gases have the neuroprotective effects. For example, xenon has been extensively studied in various animal models of neurological injury including stroke, hypoxic-ischemic encephalopathy. Compared to xenon, Argon, as a noble gas, is abundant, cheap and widely applicable, and has been also demonstrated to be neuroprotective in many research studies. In a variety of models, ranging from oxygen-glucose deprivation in cell culture to complex models of mid-cerebral artery occlusion, subarachnoid hemorrhage or retinal ischemia-reperfusion injury in animals. Argon administration after individual injury demonstrated favorable effects, particularly increased cell survival and even improved neuronal function. Therefore the neuroprotective effects of argon may be of possible clinical use for opening a potential therapeutic window in stroke. It is important to illuminate the mechanisms of argon in nerve function and to explore the best use of this gas in stroke treatment.

| S-EPMC6070843 | biostudies-other

Argon Laser Photoablation for Treating Benign Pigmented Conjunctival Nevi.

Project description:PurposeTo evaluate the outcomes of argon laser photoablation of benign conjunctival pigmented nevi with different clinical presentations.Patients and methodsThis interventional case series was conducted between July 2014 and January 2015. Patients presenting with benign conjunctival nevi were included. Data were collected on the clinical features at presentation, argon laser photoablation, and follow-up at 8 and 24 weeks. Postoperative photography allowed recording of the success of each case and the overall success rate. Complete removal of conjunctival pigments was considered an absolute success. Partial pigmentation requiring repeat laser treatment was considered a qualified success.ResultsThere were 14 eyes (four right eyes and ten left eyes) with benign pigmented conjunctival nevi. There were three males and eight females in the study sample. The median age was 36 (25% percentile: 26 years). Three patients had bilateral lesions. The nevi were located temporally in nine eyes, nasally in three eyes, and on the inferior bulbar conjunctiva in two eyes. The mean horizontal and vertical diameters of nevi were 5 ± 2 mm and 4 ± 2.7 mm, respectively. The mean follow-up period was 5 months. Following laser treatment, no eyes had subconjunctival hemorrhage, infection, scarring, neovascularization, recurrence, or corneal damage. The absolute success rate of laser ablation was 79%. Three eyes with elevated nevi had one to three sessions of laser ablation resulting in a qualified success rate of 100%.ConclusionsArgon laser ablation was a safe and effective treatment for the treatment of selective benign pigmented conjunctival nevi in Arab patients.

| S-EPMC4968145 | biostudies-literature

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| S-EPMC5456652 | biostudies-literature

Dynamic behavior of a rotary nanomotor in argon environments.

Project description:When argon is used as a protecting gas in the fabrication or working environment of a nanodevice, absorption of some argon atoms onto the surface of the device lead to different responses. In this work, the rotation of the rotor in a carbon nanotube (CNT)-based rotary nanomotor in argon environment is investigated. In the rotary nanomotor, two outer CNTs act as the stator and are used to constrain the inner CNT (i.e., the rotor). The rotor is driven to rotate by the stator due to their collision during thermal vibration of their atoms. A stable rotational frequency (SRF) of the rotor occurs when the rotor reaches a dynamic equilibrium state. The value of the SRF decreases exponentially with an increase in the initial argon density. At dynamic equilibrium date, some of the argon atoms rotate synchronously with the rotor when they are absorbed onto either internal or external surface of the rotor. The interaction between the rest of the argon atoms and the rotor is stronger at higher densities of argon, resulting in lower values of the SRF. These principles provide insight for future experimentation and fabrication of such rotary nanomotor.

| S-EPMC5823920 | biostudies-literature

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