Ontology highlight
ABSTRACT:
SUBMITTER: Ammer AG
PROVIDER: S-EPMC2875552 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Ammer Amanda Gatesman AG Kelley Laura C LC Hayes Karen E KE Evans Jason V JV Lopez-Skinner Lesly Ann LA Martin Karen H KH Frederick Barbara B Rothschild Brian L BL Raben David D Elvin Paul P Green Tim P TP Weed Scott A SA
Journal of cancer science & therapy 20091101 2
Elevated Src kinase activity is linked to the progression of solid tumors, including head and neck squamous cell carcinoma (HNSCC). Src regulates HNSCC proliferation and tumor invasion, with the Src-targeted small molecule inhibitor saracatinib displaying potent anti-invasive effects in preclinical studies. However, the pro-invasive cellular mechanism(s) perturbed by saracatinib are unclear. The anti-proliferative and anti-invasive effects of saracatinib on HNSCC cell lines were therefore invest ...[more]