The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis.
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ABSTRACT:
SUBMITTER: Willcocks LC
PROVIDER: S-EPMC2875655 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
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The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis.
Willcocks Lisa C LC Lyons Paul A PA Rees Andrew J AJ Smith Kenneth G C KG
Arthritis research & therapy 20100215 1
The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may play a role in the pathogenesis of the disease: genetics and infection. In particular, we discuss the role of autoantibodies to LAMP-2, which may arise following infection with Gram-negative bacteria, and may contribute to the development of ANCA-associated systemic vasculitis in genetically susceptible individuals. ...[more]
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