Ontology highlight
ABSTRACT:
SUBMITTER: Jastrzebska B
PROVIDER: S-EPMC2875673 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Jastrzebska Beata B Tsybovsky Yaroslav Y Palczewski Krzysztof K
The Biochemical journal 20100428 1
Activation of GPCRs (G-protein-coupled receptors) leads to conformational changes that ultimately initiate signal transduction. Activated GPCRs transiently combine with and activate heterotrimeric G-proteins resulting in GTP replacement of GDP on the G-protein alpha subunit. Both the detailed structural changes essential for productive GDP/GTP exchange on the G-protein alpha subunit and the structure of the GPCR-G-protein complex itself have yet to be elucidated. Nevertheless, transient GPCR-G-p ...[more]