Ontology highlight
ABSTRACT:
SUBMITTER: Menon T
PROVIDER: S-EPMC2875808 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Menon Tushar T Yates Joel A JA Bochar Daniel A DA
Molecular endocrinology (Baltimore, Md.) 20100322 6
The androgen receptor (AR) mediates the effect of androgens through its transcriptional function during both normal prostate development and in the emergence and progression of prostate cancer. AR is known to assemble coactivator complexes at target promoters to facilitate transcriptional activation in response to androgens. Here we identify the ATP-dependent chromatin remodeling factor chromodomain helicase DNA-binding protein 8 (CHD8) as a novel coregulator of androgen-responsive transcription ...[more]