Ontology highlight
ABSTRACT:
SUBMITTER: Haussecker D
PROVIDER: S-EPMC2876191 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Haussecker Dirk D Cao Dan D Huang Yong Y Parameswaran Poornima P Fire Andrew Z AZ Kay Mark A MA
Nature structural & molecular biology 20080615 7
The evolutionary origin of human hepatitis delta virus (HDV) replication by RNA-directed transcription is unclear. Here we identify two species of 5'-capped, approximately 18-25-nucleotide small RNAs. One was of antigenomic polarity, corresponding to the 5' end of hepatitis delta antigen (HDAg) mRNA, and interacted with HDAg and RNA polymerase II (Pol II), whereas the other mapped to a structurally analogous region on the genomic RNA hairpin. An HDAg-interaction screen indicated that HDAg intera ...[more]