Mutant prevention concentrations of four carbapenems against gram-negative rods.
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ABSTRACT:
SUBMITTER: Credito K
PROVIDER: S-EPMC2876356 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
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Mutant prevention concentrations of four carbapenems against gram-negative rods.
Credito Kim K Kosowska-Shick Klaudia K Appelbaum Peter C PC
Antimicrobial agents and chemotherapy 20100322 6
We tested the propensities of four carbapenems to select for resistant Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii mutants by determining the mutant prevention concentrations (MPCs) for 100 clinical strains with various ss-lactam phenotypes. Among the members of the Enterobacteriaceae family and A. baumannii strains, the MPC/MIC ratios were mostly 2 to 4. In contrast, for P. aeruginosa the MPC/MIC ratios were 4 to > or =16. The MPC/MIC ratios for ...[more]
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