Ontology highlight
ABSTRACT:
SUBMITTER: Wang MZ
PROVIDER: S-EPMC2876428 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Wang Michael Zhuo MZ Zhu Xiaohua X Srivastava Anuradha A Liu Qiang Q Sweat J Mark JM Pandharkar Trupti T Stephens Chad E CE Riccio Ed E Parman Toufan T Munde Manoj M Mandal Swati S Madhubala Rentala R Tidwell Richard R RR Wilson W David WD Boykin David W DW Hall James Edwin JE Kyle Dennis E DE Werbovetz Karl A KA
Antimicrobial agents and chemotherapy 20100405 6
Arylimidamides (AIAs) represent a new class of molecules that exhibit potent antileishmanial activity (50% inhibitory concentration [IC(50)], <1 microM) against both Leishmania donovani axenic amastigotes and intracellular Leishmania, the causative agent for human visceral leishmaniasis (VL). A systematic lead discovery program was employed to characterize in vitro and in vivo antileishmanial activities, pharmacokinetics, mutagenicities, and toxicities of two novel AIAs, DB745 and DB766. They we ...[more]