Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.
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ABSTRACT:
SUBMITTER: Bishop KD
PROVIDER: S-EPMC2876711 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
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Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.
Bishop Kenneth D KD Harris John E JE Mordes John P JP Greiner Dale L DL Rossini Aldo A AA Czech Michael P MP Phillips Nancy E NE
Cellular immunology 20090223 1-2
Recent studies have implicated the cell surface receptor Programmed Death-1 (PD-1) in numerous models of T cell anergy, though the specific mechanisms by which the PD-1 signal maintains tolerance is not clear. We demonstrate that the depletion of PD-1 with siRNA results in a complete reversal of clonal anergy in the A.E7 T cell model, suggesting that the mechanism by which PD-1 maintains the anergic phenotype is a T-cell-intrinsic phenomenon, and not one dependent on other cell populations in vi ...[more]
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