Ontology highlight
ABSTRACT:
SUBMITTER: Caldovic L
PROVIDER: S-EPMC2876818 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Caldovic Ljubica L Ah Mew Nicholas N Shi Dashuang D Morizono Hiroki H Yudkoff Marc M Tuchman Mendel M
Molecular genetics and metabolism 20100226
N-acetylglutamate (NAG) is a unique enzyme cofactor, essential for liver ureagenesis in mammals while it is the first committed substrate for de novo arginine biosynthesis in microorganisms and plants. The enzyme that produces NAG from glutamate and CoA, NAG synthase (NAGS), is allosterically inhibited by arginine in microorganisms and plants and activated in mammals. This transition of the allosteric effect occurred when tetrapods moved from sea to land. The first mammalian NAGS gene (from mous ...[more]