Fine scale mapping of the breast cancer 16q12 locus.
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ABSTRACT:
SUBMITTER: Udler MS
PROVIDER: S-EPMC2876886 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Fine scale mapping of the breast cancer 16q12 locus.
Udler Miriam S MS Ahmed Shahana S Healey Catherine S CS Meyer Kerstin K Struewing Jeffrey J Maranian Melanie M Kwon Erika M EM Zhang Jinghui J Tyrer Jonathan J Karlins Eric E Platte Radka R Kalmyrzaev Bolot B Dicks Ed E Field Helen H Maia Ana-Teresa AT Prathalingam Radhika R Teschendorff Andrew A McArthur Stewart S Doody David R DR Luben Robert R Caldas Carlos C Bernstein Leslie L Kolonel Laurence K LK Henderson Brian E BE Wu Anna H AH Le Marchand Loic L Ursin Giske G Press Michael F MF Lindblom Annika A Margolin Sara S Shen Chen-Yang CY Yang Show-Lin SL Hsiung Chia-Ni CN Kang Daehee D Yoo Keun-Young KY Noh Dong-Young DY Ahn Sei-Hyun SH Malone Kathleen E KE Haiman Christopher A CA Pharoah Paul D PD Ponder Bruce A J BA Ostrander Elaine A EA Easton Douglas F DF Dunning Alison M AM
Human molecular genetics 20100323 12
Recent genome-wide association studies have identified a breast cancer susceptibility locus on 16q12 with an unknown biological basis. We used a set of single nucleotide polymorphism (SNP) markers to generate a fine-scale map and narrowed the region of association to a 133 kb DNA segment containing the largely uncharacterized hypothetical gene LOC643714, a short intergenic region and the 5' end of TOX3. Re-sequencing this segment in European subjects identified 293 common polymorphisms, includin ...[more]
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