Ontology highlight
ABSTRACT:
SUBMITTER: Herranz H
PROVIDER: S-EPMC2876971 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Herranz Héctor H Hong Xin X Pérez Lidia L Ferreira Ana A Olivieri Daniel D Cohen Stephen M SM Milán Marco M
The EMBO journal 20100416 10
MicroRNAs (miRNAs) have been implicated in cell-cycle regulation and in some cases shown to have a role in tissue growth control. Depletion of miRNAs was found to have an effect on tissue growth rates in the wing primordium of Drosophila, a highly proliferative epithelium. Dicer-1 (Dcr-1) is a double-stranded RNAseIII essential for miRNA biogenesis. Adult cells lacking dcr-1, or with reduced dcr-1 activity, were smaller than normal cells and gave rise to smaller wings. dcr-1 mutant cells showed ...[more]