Ontology highlight
ABSTRACT:
SUBMITTER: Rizzi M
PROVIDER: S-EPMC2877104 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Rizzi Marta M Knoth Rolf R Hampe Christiane S CS Lorenz Peter P Gougeon Marie-Lise ML Lemercier Brigitte B Venhoff Nils N Ferrera Francesca F Salzer Ulrich U Thiesen Hans-Jürgen HJ Peter Hans-Hartmut HH Walker Ulrich A UA Eibel Hermann H
PloS one 20100526 5
Stiff person syndrome (SPS) is a rare, neurological disorder characterized by sudden cramps and spasms. High titers of enzyme-inhibiting IgG autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GAD65) are a hallmark of SPS, implicating an autoimmune component in the pathology of the syndrome. Studying the B cell compartment and the anti-GAD65 B cell response in two monozygotic twins suffering from SPS, who were treated with the B cell-depleting monoclonal anti-CD20 antibody r ...[more]