Ontology highlight
ABSTRACT:
SUBMITTER: Kedlaya RH
PROVIDER: S-EPMC2877380 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Kedlaya Rajendra H RH Bhat Kumar M R KM Bhat Kumar M R KM Mitchell Julie J Darnell Steven J SJ Setaluri Vijayasaradhi V
Archives of biochemistry and biophysics 20060823 2
PDZ proteins coordinate assembly of protein complexes that participate in diverse biological processes. GIPC is a multifunctional PDZ protein that interacts with several soluble and membrane proteins. Unlike most PDZ proteins, GIPC contains single PDZ domain and the mechanisms by which GIPC mediates its actions remain unclear. We investigated the possibility that in lieu of multiple PDZ domains, GIPC forms multimers. Here, we demonstrate that GIPC can bind to itself and that the PDZ domain is in ...[more]