Ontology highlight
ABSTRACT:
SUBMITTER: Gore Y
PROVIDER: S-EPMC2877644 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Gore Yael Y Lantner Frida F Hart Gili G Shachar Idit I
Molecular biology of the cell 20100407 11
Immature B cells migrate to the spleen where they differentiate into mature cells. This final maturation step is crucial to enable B cells to become responsive to antigens and to participate in the immune response. Previously, we showed that Id2 acts as a negative regulator of the differentiation of immature B cells occurring in the spleen. Id2 expression has been found to depend on Myc-Max-Mad transcriptional complexes in mammary epithelial cells. Nearly all studies to date have shown that Mad ...[more]