Ontology highlight
ABSTRACT:
SUBMITTER: Griner EM
PROVIDER: S-EPMC2878072 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Griner Erin M EM Caino M Cecilia MC Sosa Maria Soledad MS Colón-González Francheska F Chalmers Michael J MJ Mischak Harald H Kazanietz Marcelo G MG
The Journal of biological chemistry 20100324 22
Although the family of chimaerin Rac-GAPs has recently gained significant attention for their involvement in development, cancer, and neuritogenesis, little is known about their molecular regulation. Chimaerins are activated by the lipid second messenger diacylglycerol via their C1 domain upon activation of tyrosine kinase receptors, thereby restricting the magnitude of Rac signaling in a receptor-regulated manner. Here we identified a novel regulatory mechanism for beta2-chimaerin via phosphory ...[more]