Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC2878378 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Wang Xiaoru X Sena Filho José G JG Hoover Ashley R AR King Jarrod B JB Ellis Trevor K TK Powell Douglas R DR Cichewicz Robert H RH
Journal of natural products 20100501 5
Chemical epigenetic manipulation of Penicillium citreonigrum led to profound changes in the secondary metabolite profile of its guttate. While guttate from control cultures exhibited a relatively simple assemblage of secondary metabolites, the guttate collected from cultures treated with 50 muM 5-azacytidine (a DNA methyltransferase inhibitor) was highly enriched in compounds representing at least three distinct biosynthetic families. The metabolites obtained from the fungus included six azaphil ...[more]