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Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida.

ABSTRACT: Four new prenylated flavonoids (1-4), a new stilbenoid (5), and nine known compounds were isolated from the twigs of Artocarpus rigida, collected in Indonesia. The structures of the new compounds were determined by analysis of their spectroscopic data, and the absolute configuration at C-12 of 1 and 2 and the known compounds artonin O (6), artobiloxanthone (7), and cycloartobiloxanthone (8) was determined from their CD and NMR spectroscopic data. Several of the compounds obtained were cytotoxic toward HT-29 human colon cancer cells, with the most potent being compound 2 and the known compounds 6 and 8. Of the substances obtained, compounds 1 and 7 were the most active in the NF-kappaB p50 and p65 assay, respectively.

SUBMITTER: Ren Y

PROVIDER: S-EPMC2878397 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida.

Ren Yulin Y Kardono Leonardus B S LB Riswan Soedarsono S Chai Heebyung H Farnsworth Norman R NR Soejarto Djaja D DD Carcache de Blanco Esperanza J EJ Kinghorn A Douglas AD

Journal of natural products 20100501 5

Four new prenylated flavonoids (1-4), a new stilbenoid (5), and nine known compounds were isolated from the twigs of Artocarpus rigida, collected in Indonesia. The structures of the new compounds were determined by analysis of their spectroscopic data, and the absolute configuration at C-12 of 1 and 2 and the known compounds artonin O (6), artobiloxanthone (7), and cycloartobiloxanthone (8) was determined from their CD and NMR spectroscopic data. Several of the compounds obtained were cytotoxic ...[more]

PMID: 20384315

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