Ontology highlight
ABSTRACT:
SUBMITTER: Ojha AK
PROVIDER: S-EPMC2878501 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Ojha Anil K AK Trivelli Xavier X Guerardel Yann Y Kremer Laurent L Hatfull Graham F GF
The Journal of biological chemistry 20100407 23
Mycobacterial species, like other microbes, spontaneously form multicellular drug-tolerant biofilms when grown in vitro in detergent-free liquid media. The structure of Mycobacterium tuberculosis biofilms is formed through genetically programmed pathways and is built upon a large abundance of novel extracellular free mycolic acids (FM), although the mechanism of FM synthesis remained unclear. Here we show that the FM in Mycobacterium smegmatis biofilms is produced through the enzymatic release f ...[more]