Ontology highlight
ABSTRACT:
SUBMITTER: Burdon KP
PROVIDER: S-EPMC2878676 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Burdon Kathryn P KP Rudock Megan E ME Lehtinen Allison B AB Langefeld Carl D CD Bowden Donald W DW Register Thomas C TC Liu Yongmei Y Freedman Barry I BI Carr J Jeffrey JJ Hedrick Catherine C CC Rich Stephen S SS
Mediators of inflammation 20100531
<h4>Aims</h4>Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds.<h4>Methods</h4>Families with two or more siblings with type 2 diabetes and their nondiabetic siblings were studied as part of the Diabetes Heart Study (DHS). European American diabetic (n = 828) and nondiabetic (n = 170) siblings were genotyped for SN ...[more]