Mutational bias shaping fly copy number variation: implications for genome evolution.
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ABSTRACT:
SUBMITTER: Cardoso-Moreira MM
PROVIDER: S-EPMC2878862 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Mutational bias shaping fly copy number variation: implications for genome evolution.
Cardoso-Moreira Margarida M MM Long Manyuan M
Trends in genetics : TIG 20100421 6
Copy number variants (CNVs) underlie several genomic disorders and are a major source of genetic innovation. Consequently, any bias affecting their placement in the genome will impact our understanding of human disease and genome evolution. Here we report a mutational bias affecting CNVs that generates different probabilities of duplication and deletion across the genome in association with DNA replication time. We show that this mutational bias has important consequences for genome evolution by ...[more]
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