Ontology highlight
ABSTRACT:
SUBMITTER: Daubert EA
PROVIDER: S-EPMC2878889 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Daubert Elizabeth A EA Heffron Daniel S DS Mandell James W JW Condron Barry G BG
Molecular and cellular neurosciences 20100413 3
Administration of certain serotonin-releasing amphetamine derivatives (fenfluramine and/or 3,4-methylenedioxymethamphetamine, MDMA, 'ecstasy') results in dystrophic serotonergic morphology in the mammalian brain. In addition to drug administration, dystrophic serotonergic neurites are also associated with neurodegenerative disorders. We demonstrate here that endogenously elevated serotonin in the Drosophila CNS induces aberrant enlarged varicosities, or spheroids, that are morphologically simila ...[more]