Ontology highlight
ABSTRACT:
SUBMITTER: Reynolds JM
PROVIDER: S-EPMC2878917 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Immunity 20100429 5
Toll-like receptors (TLRs) have previously been shown to play critical roles in the activation of innate immunity. Here, we describe that T cell expression of TLR2 regulates T helper 17 (Th17) cell responses. Stimulation with TLR2 agonists promoted Th17 differentiation in vitro and led to more robust proliferation and Th17 cytokine production. Using the experimental autoimmune encephalomyelitis (EAE) model, we found that TLR2 regulated Th17 cell-mediated autoimmunity in vivo and that loss of TLR ...[more]