Ontology highlight
ABSTRACT:
SUBMITTER: Gill DJ
PROVIDER: S-EPMC2878949 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Gill David J DJ Chia Joanne J Senewiratne Jamie J Bard Frederic F
The Journal of cell biology 20100524 5
After growth factor stimulation, kinases are activated to regulate multiple aspects of cell physiology. Activated Src is present on Golgi membranes, but its function here remains unclear. We find that Src regulates mucin-type protein O-glycosylation through redistribution of the initiating enzymes, polypeptide N-acetylgalactosaminyl transferases (GalNac-Ts), from the Golgi to the ER. Redistribution occurs after stimulation with EGF or PDGF in a Src-dependent manner and in cells with constitutive ...[more]