Ontology highlight
ABSTRACT:
SUBMITTER: Brautigam CA
PROVIDER: S-EPMC2879633 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Brautigam Chad A CA Wynn R Max RM Chuang Jacinta L JL Machius Mischa M Tomchick Diana R DR Chuang David T DT
Structure (London, England : 1993) 20060126 3
The 9.5 MDa human pyruvate dehydrogenase complex (PDC) utilizes the specific dihydrolipoamide dehydrogenase (E3) binding protein (E3BP) to tether the essential E3 component to the 60-meric core of the complex. Here, we report crystal structures of the binding domain (E3BD) of human E3BP alone and in complex with human E3 at 1.6 angstroms and 2.2 angstroms, respectively. The latter structure shows that residues from E3BD contact E3 across its 2-fold axis, resulting in one E3BD binding site on the ...[more]