Ontology highlight
ABSTRACT:
SUBMITTER: Chan MR
PROVIDER: S-EPMC2879708 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Chan Micah R MR Thomas Christie P CP Torrealba Jose R JR Djamali Arjang A Fernandez Luis A LA Nishimura Carla J CJ Smith Richard J H RJ Samaniego Millie D MD
American journal of kidney diseases : the official journal of the National Kidney Foundation 20080921 2
Atypical hemolytic uremic syndrome, or the nondiarrheal form of hemolytic uremic syndrome, is a rare disorder typically classified as familial or sporadic. Recent literature has suggested that approximately 50% of patients have mutations in factor H (CFH), factor I (CFI), or membrane cofactor protein (encoded by CD46). Importantly, results of renal transplantation in patients with mutations in either CFH or CFI are dismal, with recurrent disease leading to graft loss in the majority of cases. We ...[more]