Ontology highlight
ABSTRACT:
SUBMITTER: Passarella RJ
PROVIDER: S-EPMC2880200 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Passarella Ralph J RJ Spratt Daniel E DE van der Ende Alice E AE Phillips John G JG Wu Hongmei H Sathiyakumar Vasanth V Zhou Li L Hallahan Dennis E DE Harth Eva E Diaz Roberto R
Cancer research 20100518 11
To capitalize on the response of tumor cells to XRT, we developed a controlled-release nanoparticle drug delivery system using a targeting peptide that recognizes a radiation-induced cell surface receptor. Phage display biopanning identified Gly-Ile-Arg-Leu-Arg-Gly (GIRLRG) as a peptide that selectively recognizes tumors responding to XRT. Membrane protein extracts of irradiated glioma cells identified glucose-regulated protein GRP78 as the receptor target for GIRLRG. Antibodies to GRP78 blocked ...[more]