Ontology highlight
ABSTRACT:
SUBMITTER: Palaniswamy R
PROVIDER: S-EPMC2880320 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Palaniswamy Ramesh R Teglund Stephan S Lauth Matthias M Zaphiropoulos Peter G PG Shimokawa Takashi T
BMC molecular biology 20100430
<h4>Background</h4>Alternative splicing is one of the key mechanisms that generate biological diversity. Even though alternative splicing also occurs in the 5' and 3' untranslated regions (UTRs) of mRNAs, the understanding of the significance and the regulation of these variations is rather limited.<h4>Results</h4>We investigated 5' UTR mRNA variants of the mouse Gli1 oncogene, which is the terminal transcriptional effector of the Hedgehog (HH) signaling pathway. In addition to identifying novel ...[more]