Ontology highlight
ABSTRACT:
SUBMITTER: Brynskikh AM
PROVIDER: S-EPMC2880389 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Brynskikh Anna M AM Zhao Yuling Y Mosley R Lee RL Li Shu S Boska Michael D MD Klyachko Natalia L NL Kabanov Alexander V AV Gendelman Howard E HE Batrakova Elena V EV
Nanomedicine (London, England) 20100401 3
<h4>Background</h4>Parkinson's disease is a common progressive neurodegenerative disorder associated with profound nigrostriatal degeneration. Regrettably, no therapies are currently available that can attenuate disease progression. To this end, we developed a cell-based nanoformulation delivery system using the antioxidant enzyme catalase to attenuate neuroinflammatory processes linked to neuronal death.<h4>Methods</h4>Nanoformulated catalase was obtained by coupling catalase to a synthetic pol ...[more]