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Targeting the cancer kinome through polypharmacology.

ABSTRACT: Kinase inhibitors are the largest class of new cancer drugs. However, it is already apparent that most tumours can escape from the inhibition of any single kinase. If it is necessary to inhibit multiple kinases, how do we choose which ones? In this Opinion article, we discuss some of the strategies that are currently being used to identify new therapeutic combinations of kinase targets.

SUBMITTER: Knight ZA

PROVIDER: S-EPMC2880454 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Targeting the cancer kinome through polypharmacology.

Knight Zachary A ZA Lin Henry H Shokat Kevan M KM

Nature reviews. Cancer 20100201 2

Kinase inhibitors are the largest class of new cancer drugs. However, it is already apparent that most tumours can escape from the inhibition of any single kinase. If it is necessary to inhibit multiple kinases, how do we choose which ones? In this Opinion article, we discuss some of the strategies that are currently being used to identify new therapeutic combinations of kinase targets. ...[more]

PMID: 20094047

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