Cholesterol-phospholipid interactions: new insights from surface x-ray scattering data.
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ABSTRACT:
SUBMITTER: Ivankin A
PROVIDER: S-EPMC2880613 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Cholesterol-phospholipid interactions: new insights from surface x-ray scattering data.
Ivankin Andrey A Kuzmenko Ivan I Gidalevitz David D
Physical review letters 20100308 10
We report a structural study of cholesterol-DPPC (1,2-dipalmitoyl-sn-glycero-3-phophocholine) monolayers using x-ray reflectivity and grazing incidence x-ray diffraction. Reflectivity reveals that the vertical position of cholesterol relative to phospholipids strongly depends on its mole fraction (chi(CHOL)). Moreover, we find that at a broad range of chi(CHOL) cholesterol and DPPC form alloylike mixed domains of short-range order and the same stoichiometry as that of the film. Based on the data ...[more]
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