Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC2880636 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20090301 5
Opioid receptor selective antagonists are important pharmacological probes in opioid receptor structural characterization and opioid agonist functional study. Thus far, a nonpeptidyl, highly selective and reversible mu opioid receptor (MOR) antagonist is unavailable. On the basis of our modeling studies, a series of novel naltrexamine derivatives have been designed and synthesized. Among them, two compounds were identified as leads based on the results of in vitro and in vivo assays. Both of the ...[more]