Dataset Information

Vitamin E and age-related macular degeneration in a randomized trial of women.

ABSTRACT:

Objective

To test whether alternate day vitamin E affects the incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women.

Design

Randomized, double-masked, placebo-controlled trial.

Participants

Thirty-nine thousand eight hundred seventy-six apparently healthy female health professionals aged 45 years or older.

Intervention

Participants were assigned randomly to receive either 600 IU of natural-source vitamin E on alternate days or placebo.

Main outcome measures

Incident AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-report confirmed by medical record review.

Results

After 10 years of treatment and follow-up, there were 117 cases of AMD in the vitamin E group and 128 cases in the placebo group (relative risk, 0.93; 95% confidence interval, 0.72-1.19).

Conclusions

In a large-scale randomized trial of female health professionals, long-term alternate-day use of 600 IU of natural-source vitamin E had no large beneficial or harmful effect on risk of AMD.

SUBMITTER: Christen WG

PROVIDER: S-EPMC2881167 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Vitamin E and age-related macular degeneration in a randomized trial of women.

Christen William G WG Glynn Robert J RJ Chew Emily Y EY Buring Julie E JE

Ophthalmology 20100213 6

<h4>Objective</h4>To test whether alternate day vitamin E affects the incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women.<h4>Design</h4>Randomized, double-masked, placebo-controlled trial.<h4>Participants</h4>Thirty-nine thousand eight hundred seventy-six apparently healthy female health professionals aged 45 years or older.<h4>Intervention</h4>Participants were assigned randomly to receive either 600 IU of natural-source vitamin E on alternate days or ...[more]

PMID: 20153900

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Dataset Information

Vitamin E and age-related macular degeneration in a randomized trial of women.

Objective

Design

Participants

Intervention

Main outcome measures

Results

Conclusions

Publications

Vitamin E and age-related macular degeneration in a randomized trial of women.

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