Ontology highlight
ABSTRACT:
SUBMITTER: Park SJ
PROVIDER: S-EPMC2881208 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Park So-Jung SJ Kufareva Irina I Abagyan Ruben R
Journal of computer-aided molecular design 20100509 5
Nuclear receptors (NRs) are ligand dependent transcriptional factors and play a key role in reproduction, development, and homeostasis of organism. NRs are potential targets for treatment of cancer and other diseases such as inflammatory diseases, and diabetes. In this study, we present a comprehensive library of pocket conformational ensembles of thirteen human nuclear receptors (NRs), and test the ability of these ensembles to recognize their ligands in virtual screening, as well as predict th ...[more]