Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC2881480 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Yang Ling L Li Ping P Fu Suneng S Calay Ediz S ES Hotamisligil Gökhan S GS
Cell metabolism 20100601 6
Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic components, including damaged organelles and proteins. In both genetic and dietary models of obesity, we observed a severe downregulation of autophagy, particularly in Atg7 expression levels in liver. Suppression of Atg7 both in vitro and in vivo resulted in defective insulin signaling and elevated ER stress. In contrast, restoration of the Atg7 expression in liver resulted in dampened ER stress, enhanced hepatic ...[more]