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Increasing levels of free thyroxine as a risk factor for a first venous thrombosis: a case-control study.


ABSTRACT: A hypercoagulable state exists in hyperthyroidism, but the association with venous thrombosis (VT) is not fully explored. We aimed to investigate VT risk for different plasma levels of thyroid hormones and thyroid antibodies. We used a case-control study on leg vein thrombosis conducted between September 1999 and August 2006 at the Academic Medical Center, Amsterdam, The Netherlands. Parameters of thyroid function were assessed in 190 cases (mean age, 57 years; range, 19-90 years) and 379 sex-matched controls (mean age, 56 years; range, 18-93 years). Odds ratios (ORs) and 95% confidence intervals (CIs) for VT risk were estimated according to several cutoff levels derived from plasma levels observed in controls. We found the risk of VT to gradually rise with increasing levels of free thyroxine (FT(4)). In the absence of traditional acquired risk factors, FT(4) levels above 17 pmol/L yielded a sex- and age-adjusted OR of 2.2 (95% CI, 1.2-4.2) for deep VT, which further increased up to an OR of 13.0 (95% CI, 1.1-154.1) for FT(4) levels above reference range. Our data suggest increasing levels of FT(4) to be a risk factor for VT and may have implications for both the prevention and management of this disease.

SUBMITTER: van Zaane B 

PROVIDER: S-EPMC2881489 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Increasing levels of free thyroxine as a risk factor for a first venous thrombosis: a case-control study.

van Zaane Bregje B   Squizzato Alessandro A   Huijgen Roeland R   van Zanten Anton P AP   Fliers Eric E   Cannegieter Suzanne C SC   Büller Harry R HR   Gerdes Victor E A VE   Brandjes Dees P M DP  

Blood 20100322 22


A hypercoagulable state exists in hyperthyroidism, but the association with venous thrombosis (VT) is not fully explored. We aimed to investigate VT risk for different plasma levels of thyroid hormones and thyroid antibodies. We used a case-control study on leg vein thrombosis conducted between September 1999 and August 2006 at the Academic Medical Center, Amsterdam, The Netherlands. Parameters of thyroid function were assessed in 190 cases (mean age, 57 years; range, 19-90 years) and 379 sex-ma  ...[more]

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