Unknown

Dataset Information

0

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

ABSTRACT: In a genome-wide screen of 684 cancer cell lines, we identified homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. Among these, PARD3 is disrupted in cell lines and primary tumors from squamous carcinomas and glioblastomas. Reconstituting PARD3 expression in both cell types restores tight junctions and retards contact-dependent proliferation. Searching specifically for small intragenic microdeletions using high-resolution genomic arrays may be complementary to other genomic deletion screens and resequencing efforts in identifying new tumor suppressor genes.

SUBMITTER: Rothenberg SM 

PROVIDER: S-EPMC2881662 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

In a genome-wide screen of 684 cancer cell lines, we identified homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. Among these, PARD3 is disrupted in cell lines and primary tumors from squamous carcinomas and glioblastomas. Reconstituting PARD3 expression in both cell types restores tight junctions and retards contact-dependent proliferation. Searching specifically for small intragenic microdeletions using high-resolution genomic  ...[more]

Similar Datasets

Transcriptomics A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
2011-11-03 | E-GEOD-20306 | biostudies-arrayexpress
Genomics A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
2011-11-03 | GSE20306 | GEO
Unknown A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity.
| S-EPMC3086096 | biostudies-literature
Unknown A genome-wide screen identifies frequently methylated genes in haematological and epithelial cancers.
| S-EPMC2838813 | biostudies-literature
Unknown A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation.
| S-EPMC5932228 | biostudies-literature
Unknown A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.
| S-EPMC2772893 | biostudies-literature
Unknown Genome-wide RNAi screen reveals a role for the ESCRT complex in rotavirus cell entry.
| S-EPMC3690850 | biostudies-other
Unknown Genome-Wide CRISPR Screen Reveals Autophagy Disruption as the Convergence Mechanism That Regulates the NRF2 Transcription Factor.
| S-EPMC6580702 | biostudies-literature
Unknown Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection.
| S-EPMC7457610 | biostudies-literature
Unknown A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans.
| S-EPMC3522167 | biostudies-literature