Ontology highlight
ABSTRACT:
SUBMITTER: Staples GO
PROVIDER: S-EPMC2881759 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Staples Gregory O GO Shi Xiaofeng X Zaia Joseph J
The Journal of biological chemistry 20100402 24
Heparan sulfate (HS) serves as a cell-surface co-receptor for growth factors, morphogens, and chemokines. These HS and protein binding events depend on the fine structure and distribution of domains along an HS chain. A given domain can vary in terms of uronic acid epimer, N- and O-sulfate, and N-acetate content. The most highly sulfated regions of HS chains, N-sulfated (NS) domains, play prominent roles in HS and protein binding. We have analyzed HS oligosaccharides from various mammalian sourc ...[more]