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The innate immune response in leprosy.

ABSTRACT: Investigation into the innate immune response in leprosy has provided insight into immunoregulation in human infectious disease. Key advances include the role of pattern recognition receptors in recognizing pathogen-associated molecular patterns of Mycobacterium leprae, cytokine release by innate immune cells, macrophage and dendritic cell differentiation, as well as antimicrobial effector pathways. These insights provide targets for therapeutic intervention in modulating the course of leprosy and other chronic infectious diseases.

SUBMITTER: Modlin RL

PROVIDER: S-EPMC2882026 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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The innate immune response in leprosy.

Modlin Robert L RL

Current opinion in immunology 20100107 1

Investigation into the innate immune response in leprosy has provided insight into immunoregulation in human infectious disease. Key advances include the role of pattern recognition receptors in recognizing pathogen-associated molecular patterns of Mycobacterium leprae, cytokine release by innate immune cells, macrophage and dendritic cell differentiation, as well as antimicrobial effector pathways. These insights provide targets for therapeutic intervention in modulating the course of leprosy a ...[more]

PMID: 20060279

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