Ontology highlight
ABSTRACT:
SUBMITTER: Albuquerque RJ
PROVIDER: S-EPMC2882165 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Albuquerque Romulo J C RJ Hayashi Takahiko T Cho Won Gil WG Kleinman Mark E ME Dridi Sami S Takeda Atsunobu A Baffi Judit Z JZ Yamada Kiyoshi K Kaneko Hiroki H Green Martha G MG Chappell Joe J Wilting Jörg J Weich Herbert A HA Yamagami Satoru S Amano Shiro S Mizuki Nobuhisa N Alexander Jonathan S JS Peterson Martha L ML Brekken Rolf A RA Hirashima Masanori M Capoor Seema S Usui Tomohiko T Ambati Balamurali K BK Ambati Jayakrishna J
Nature medicine 20090809 9
Disruption of the precise balance of positive and negative molecular regulators of blood and lymphatic vessel growth can lead to myriad diseases. Although dozens of natural inhibitors of hemangiogenesis have been identified, an endogenous selective inhibitor of lymphatic vessel growth has not to our knowledge been previously described. We report the existence of a splice variant of the gene encoding vascular endothelial growth factor receptor-2 (Vegfr-2) that encodes a secreted form of the prote ...[more]