Genomic identification of regulatory elements by evolutionary sequence comparison and functional analysis.

ABSTRACT: Despite remarkable recent advances in genomics that have enabled us to identify most of the genes in the human genome, comparable efforts to define transcriptional cis-regulatory elements that control gene expression are lagging behind. The difficulty of this task stems from two equally important problems: our knowledge of how regulatory elements are encoded in genomes remains elementary, and there is a vast genomic search space for regulatory elements, since most of mammalian genomes are noncoding. Comparative genomic approaches are having a remarkable impact on the study of transcriptional regulation in eukaryotes and currently represent the most efficient and reliable methods of predicting noncoding sequences likely to control the patterns of gene expression. By subjecting eukaryotic ge

SUBMITTER: Loots GG 

PROVIDER: S-EPMC2882178 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature