Modulation of the vitamin D3 response by cancer-associated mutant p53.
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ABSTRACT:
SUBMITTER: Stambolsky P
PROVIDER: S-EPMC2882298 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Modulation of the vitamin D3 response by cancer-associated mutant p53.
Stambolsky Perry P Tabach Yuval Y Fontemaggi Giulia G Weisz Lilach L Maor-Aloni Revital R Siegfried Zehava Z Shiff Idit I Kogan Ira I Shay Moshe M Kalo Eyal E Blandino Giovanni G Simon Itamar I Oren Moshe M Rotter Varda V
Cancer cell 20100301 3
The p53 gene is mutated in many human tumors. Cells of such tumors often contain abundant mutant p53 (mutp53) protein, which may contribute actively to tumor progression via a gain-of-function mechanism. We applied ChIP-on-chip analysis and identified the vitamin D receptor (VDR) response element as overrepresented in promoter sequences bound by mutp53. We report that mutp53 can interact functionally and physically with VDR. Mutp53 is recruited to VDR-regulated genes and modulates their expressi ...[more]
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