Ontology highlight
ABSTRACT:
SUBMITTER: Ahn K
PROVIDER: S-EPMC2882713 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Ahn Kay K Johnson Douglas S DS Cravatt Benjamin F BF
Expert opinion on drug discovery 20090701 7
BACKGROUND: Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. Genetic or pharmacological inactivation of FAAH produces analgesic, anti-inflammatory, anxiolytic, and antidepressant phenotypes without showing the undesirable side effects of direct cannabinoid receptor agonists, indicating that FAAH may be a promising therapeutic target. OBJECTIVES: This review highlights advances in the development ...[more]