Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto T
PROVIDER: S-EPMC2882723 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Yamamoto Takashi T Watanabe Kazuhisa K Inoue Noriyuki N Nakagawa Yoshimi Y Ishigaki Naomi N Matsuzaka Takashi T Takeuchi Yoshinori Y Kobayashi Kazuto K Yatoh Shigeru S Takahashi Akimitsu A Suzuki Hiroaki H Yahagi Naoya N Gotoda Takanari T Yamada Nobuhiro N Shimano Hitoshi H
Journal of lipid research 20100223 7
Sterol-regulatory element binding protein-1c (SREBP-1c) is a transcription factor that controls lipogenesis in the liver. Hepatic SREBP-1c is nutritionally regulated, and its sustained activation causes hepatic steatosis and insulin resistance. Although regulation of SREBP-1c is known to occur at the transcriptional level, the precise mechanism by which insulin signaling activates SREBP-1c promoter remains to be elucidated. Here we show that protein kinase C beta (PKCbeta) is a key mediator of i ...[more]