Ontology highlight
ABSTRACT:
SUBMITTER: Shuck SC
PROVIDER: S-EPMC2882864 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Shuck Sarah C SC Turchi John J JJ
Cancer research 20100401 8
Targeting uncontrolled cell proliferation and resistance to DNA-damaging chemotherapeutics with a single agent has significant potential in cancer treatment. Replication protein A (RPA), the eukaryotic ssDNA-binding protein, is essential for genomic maintenance and stability via roles in both DNA replication and repair. We have identified a novel small molecule that inhibits the in vitro and cellular ssDNA-binding activity of RPA, prevents cell cycle progression, induces cytotoxicity, and increa ...[more]